Query: NC_010336:996661 Francisella philomiragia subsp. philomiragia ATCC 25017, complete Lineage: Francisella philomiragia; Francisella; Francisellaceae; Thiotrichales; Proteobacteria; Bacteria General Information: Francisella philomiragia subsp. philomiragia ATCC 25017 was isolated from water in the Bear River Refuge in Utah, USA. Causes disease in humans and fish. Francisella philomiragia, formerly Yersinia philomiragia, has been isolated from water, muskrats, fish and humans. F. philomiragia is able to cause an often fatal bacteremia in people with chronic granulomatous disease. This supspecies can also cause pneumonia in near-drowning victims.
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General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.