Query: NC_010168:1373337 Renibacterium salmoninarum ATCC 33209 chromosome, complete genome Lineage: Renibacterium salmoninarum; Renibacterium; Micrococcaceae; Actinomycetales; Actinobacteria; Bacteria General Information: This bacterial pathogen is the causal agent of bacterial kidney disease (BKD) of salmonid fish. This disease is a significant threat to the healthy and sustainable production of salmon for consumption and species conservation efforts in the USA. The development of treatments are further complicated as the organism is vertically transmitted from infected females to their eggs, is difficult to culture in vitro, and is a facultative intracellular pathogen. The completion of the genome sequence of Renibacterium salmoninarum will be a benefit to the scientific community at many levels and will be of immediate use to researchers and fish health practitioners dealing with BKD in farmed fish as well as captive broodstocks of endangered species-listed populations. For example, genome data will serve as a foundation for identification of virulence factors, DNA vaccine gene candidates, and improved diagnostic tests.
- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description
General Information: Used for the production of BCG vaccine in Japan. Causative agent of classic bovine tuberculosis. This bacterium is the causative agent of classic bovine tuberculosis, but it can also cause the disease in humans, especially if contaminated milk is consumed without prior pasteurization. The Mycobacterium bovis complex is a diverse group of species, serovars and morphotypes that cause tuberculosis-like diseases in animals and humans. Pasteurization of milk is a major preventitive factor in transmission of bovine tuberculosis to humans. However, spreading the disease through milk and dairy products is still a concern in underdeveloped countries where pasteurization is not practiced. The pathology in cows is similar to the pathology of Mycobacterium tuberculosis in humans, with pulmonary TB leading to chronic debilitation, coughing, and further systemic spread to other organs. In addition, 1 to 2% of infected cows develop mycobacterial mastitis that results in shedding of the bacteria into the milk.