Query: NC_010162:573709 Sorangium cellulosum 'So ce 56', complete genome Lineage: Sorangium cellulosum; Sorangium; Polyangiaceae; Myxococcales; Proteobacteria; Bacteria General Information: Sorangium cellulosum 'So ce 56' produces a large number of bioactive compounds, such as, the antifungal soraphen and the anticancer agent epothilone. This organism, like other myxobacteria, undergoes a complex development and differentiation pathway. When cell density increases, the organism switches to "social motility" where aggregates of cells can gather together into masses termed fruiting bodies that may consist of up to 100 000 cells. The motility system is not dependent on flagella like most bacteria, but instead relies on twitching pili: short extracellular appendages that may function analogously to oars in a rowboat. The myxobacteria have proved to be a rich source of novel natural products. Sorangium cellulosum produces a number of antibacterial, antifungal and cytotoxic substances which are being studies for therapeutic applications.
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General Information: Heliobacterium modesticaldum strain Ice1, the type strain of this species, was isolated from Icelandic hot spring volcanic soils. It grows optimally above 50 degrees Celsius, grows best photoheterotrophically, but can grow in the dark chemotrophically on pyruvate. Phototrophic thermophile. This organism is an anoxygenic phototroph isolated from hot spring microbial mats and volcanic soil. Cell wall structure, the ability to form endospores, and 16S ribosomal RNA analysis place Heliobacterium modesticaldum in a family of phototrophic bacteria related to the Clostridia. Heliobacterium modesticaldum is able to fix nitrogen and may contribute significantly to the nitrogen availability in microbial mats.