Pre_GI: SWBIT SVG BLASTP

Query: NC_010161:2050816 Bartonella tribocorum CIP 105476, complete genome

Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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BLASTP Alignment.txt

Subject: NC_003919:5056650 Xanthomonas axonopodis pv. citri str. 306, complete genome

Lineage: Xanthomonas citri; Xanthomonas; Xanthomonadaceae; Xanthomonadales; Proteobacteria; Bacteria

General Information: This organism is the causal agent of citrus canker, a bacterial infection originating from southeast Asia which now occurs worldwide. Primarily a pathogen of plants in the Citrus genus, the disease is sometimes also found in other members of the Rutaceae. The bacterium survives in leaf, shoot and fruit lesions that develop during the spring, and which also cause secondary infections. During warm, wet weather in spring and early summer, the bacterium oozes out of overwintering lesions and infects new growth via the stomal pores or wounds. The bacterium may also survive for various periods of time in the soil or associated with other hosts.