Pre_GI: SWBIT SVG BLASTP

Query: NC_010120:2029880 Neisseria meningitidis 053442, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

Subject: NC_007712:3629358 Sodalis glossinidius str. 'morsitans', complete genome

Lineage: Sodalis glossinidius; Sodalis; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Sodalis glossinidius is known exclusively in endosymbiosis with tsetse flies. It is maternally transmitted, and is one of the few bacterial endosymbionts of insects that can be cultured successfully in vitro. Genome data reveals a high proportion of pseudogenes in this species, many of which were, in their functional state, involved in defense or transport of carbohydrates and inorganic ions. This suggests a degenerative adaptation to the immunity and restricted nutritional status of the host.