Pre_GI: SWBIT SVG BLASTP

Query: NC_010120:144000 Neisseria meningitidis 053442, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

Subject: NC_006347:2899653 Bacteroides fragilis YCH46, complete genome

Lineage: Bacteroides fragilis; Bacteroides; Bacteroidaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This organism can become an opportunistic pathogen, infecting anywhere in the body and causing abcess formation. Enterotoxigenic Bacterioides fragilis (ETBF) is associated with diarrheal diseases. This strain was isolated from a patient with septicemia in Japan. Common gut bacterium. This group of microbes constitute the most abundant members of the intestinal microflora of mammals. Typically they are symbionts, but they can become opportunistic pathogens in the peritoneal (intra-abdominal) cavity. Breakdown of complex plant polysaccharides such as cellulose and hemicellulose and host-derived polysaccharides such as mucopolysaccharides is aided by the many enzymes these organisms produce. Although only a minor component of the human gut microflora, this organism is a major component of clinical specimens and is the most common anaerobe isolated.