Query: NC_009953:5193471 Salinispora arenicola CNS-205 chromosome, complete genome Lineage: Salinispora arenicola; Salinispora; Micromonosporaceae; Actinomycetales; Actinobacteria; Bacteria General Information: Found in marine sediment, this organism produces cancer-fighting compounds. Salinispora strains are commonly isolated from tropical marine sediment. Members of this genus produce branched hyphae and require media which contain seawater or sodium. A survey of the cultured species identified over 90 isolates which produce compounds that inhibited cancer cells. These organisms may be a new source of bioactive chemicals for use in disease and cancer treatments. Salinispora arenicola produces the bioactive compounds staurosporine and rifamycin which may be useful in the treatment of cancer.
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General Information: This organism, like other myxobacteria, undergoes a complex development and differentiation pathway. When cell density increases, the organism switches to "social motility" where aggregates of cells can gather together into masses termed fruiting bodies that may consist of up to 100 000 cells. The motility system is not dependent on flagella like most bacteria, but instead relies on twitching pili: short extracellular appendages that may function analogously to oars in a rowboat. The myxobacteria have proved to be a rich source of novel natural products. Myxococcus fulvus produces a number of antibacterial, antifungal and cytotoxic substances which are being studies for therapeutic applications.