Query: NC_009953:2106572 Salinispora arenicola CNS-205 chromosome, complete genome
Lineage: Salinispora arenicola; Salinispora; Micromonosporaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: Found in marine sediment, this organism produces cancer-fighting compounds. Salinispora strains are commonly isolated from tropical marine sediment. Members of this genus produce branched hyphae and require media which contain seawater or sodium. A survey of the cultured species identified over 90 isolates which produce compounds that inhibited cancer cells. These organisms may be a new source of bioactive chemicals for use in disease and cancer treatments. Salinispora arenicola produces the bioactive compounds staurosporine and rifamycin which may be useful in the treatment of cancer.
Subject: NC_008596:6009511 Mycobacterium smegmatis str. MC2 155, complete genome
Lineage: Mycobacterium smegmatis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: Causes opportunistic infections. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. Mycobacterium smegmatis was initially isolated from human smegma. It is associated with soft tissue lesions following trauma or surgery. It is also reported as a possible factor in penile carcinogenesis.