Query: NC_009922:1 Alkaliphilus oremlandii OhILAs, complete genome Lineage: Alkaliphilus oremlandii; Alkaliphilus; Clostridiaceae; Clostridiales; Firmicutes; Bacteria General Information: Arsenate-reducing bacterium. Alkaliphilus oremlandii was isolated from Ohio River sediment, USA. This organism can reduce arsenate to arsenite, making it a potential bioremediation agent. It is a versatile strict anaerobic, spore-forming, low G+C gram positive bacterium that can ferment glycerol, fructose, and lactate, as well as respire arsenate and thiosulfate.
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General Information: Causative agent for Rocky Mountain Spotted Fever. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.