Pre_GI: SWBIT SVG BLASTP

Query: NC_009831:2045811 Shewanella sediminis HAW-EB3, complete genome

Lineage: Shewanella sediminis; Shewanella; Shewanellaceae; Alteromonadales; Proteobacteria; Bacteria

General Information: Shewanella sediminis was isolated from sediment taken at a depth of 215 meters from an unexploded-ordinance-dumping site 50 nautical miles from Halifax Harbor, Canada in the Atlantic Ocean. This organism is able to degrade hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) anaerobically at 10 degrees C. RDX is a member of a family of nitramine compounds which are used in the production of explosives. Shewanella are facultatively anaerobic, Gram-negative bacteria, motile by polar flagella, rod-like, and generally associated with aquatic or marine environments.

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BLASTP Alignment.txt

Subject: NC_004337:3249791 Shigella flexneri 2a str. 301, complete genome

Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.