Query: NC_009828:469778 Thermotoga lettingae TMO, complete genome Lineage: Thermotoga lettingae; Thermotoga; Thermotogaceae; Thermotogales; Thermotogae; Bacteria General Information: Thermotoga lettingae strain TMO was isolated from a methanol-degrading, sulfate-reducing bioreactor. Thermophilic, methanol-degrading organism. This organism, a member of the Thermotogales, has the characteristic sheath-like envelope which extends beyond the cell wall. The oxidation of methanol was more efficient when Thermotoga lettingae was grown as a co-culture with Methanothermobacter thermautotrophicus or Thermodesulfovibrio yellowstonii.
- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description
General Information: Causative agent for Rocky Mountain Spotted Fever. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.