Query: NC_009828:469778 Thermotoga lettingae TMO, complete genome Lineage: Thermotoga lettingae; Thermotoga; Thermotogaceae; Thermotogales; Thermotogae; Bacteria General Information: Thermotoga lettingae strain TMO was isolated from a methanol-degrading, sulfate-reducing bioreactor. Thermophilic, methanol-degrading organism. This organism, a member of the Thermotogales, has the characteristic sheath-like envelope which extends beyond the cell wall. The oxidation of methanol was more efficient when Thermotoga lettingae was grown as a co-culture with Methanothermobacter thermautotrophicus or Thermodesulfovibrio yellowstonii.
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General Information: This strain (live vaccine strain) was created in the 1960's in the USA and provides protection against tularemia in animal models as well as in humans. Causative agent of tularemia. This organism was first identified by Edward Francis as the causative agent of a plague-like illness that affected squirrels in Tulare county in California in the early part of the 20th century. The organism now bears his name. The disease, which has been noted throughout recorded history, can be transmitted to humans by infected ticks or deerflies, infected meat, or by aerosol, and thus is a potential bioterrorism agent. This organism has a high infectivity rate, and can invade phagocytic and nonphagocytic cells, multiplying rapidly. Once within a macrophage, the organism can escape the phagosome and live in the cytosol. It is an aquatic organism, and can be found living inside protozoans, similar to what is observed with Legionella.