Query: NC_009792:4693152 Citrobacter koseri ATCC BAA-895, complete genome Lineage: Citrobacter koseri; Citrobacter; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: Citrobacter koseri ATCC BAA-895 is a clinical isolate from a human infant. Causative agent of neonatal meningitis. Citrobacter koseri, previously known as Citrobacter diversus, Levinea diversus or Levinea malonatica resides in a wide range of environments, including soil, water and food products. It is an occasional inhabitant of human and animal intestines, but is mainly characterized as being a causative agent of neonatal meningitis with an extreme high rate of multiple brain abscess initiations and a concomitant high moratility rate. The bacteria are used in neonatal rat models to study the mechanism of blood-brain barrier penetration, host immune response evasion and its resistance to phagocytotic killing.
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General Information: Citrobacter rodentium is the causative agent of transmissible murine colonic hyperplasia in mice. This disease is characterized by a hyperproliferation of the epithelial cells in the colon similar to that found in humans suffering from idiopathic inflammatory bowel disease. In addition this organism contains virulence factors similar to those found in enterohemorrhagic Escherichia coli and enteropathogenic E. coli. C. rodentium are being used as models for studying mucosal response to infection, colon tumor production, and virulence associated with pathogenic E. coli.