Query: NC_009792:1479779 Citrobacter koseri ATCC BAA-895, complete genome Lineage: Citrobacter koseri; Citrobacter; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: Citrobacter koseri ATCC BAA-895 is a clinical isolate from a human infant. Causative agent of neonatal meningitis. Citrobacter koseri, previously known as Citrobacter diversus, Levinea diversus or Levinea malonatica resides in a wide range of environments, including soil, water and food products. It is an occasional inhabitant of human and animal intestines, but is mainly characterized as being a causative agent of neonatal meningitis with an extreme high rate of multiple brain abscess initiations and a concomitant high moratility rate. The bacteria are used in neonatal rat models to study the mechanism of blood-brain barrier penetration, host immune response evasion and its resistance to phagocytotic killing.
- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description
General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.