Pre_GI: SWBIT SVG BLASTP

Query: NC_009749:1699152 Francisella tularensis subsp. holarctica FTA, complete genome

Lineage: Francisella tularensis; Francisella; Francisellaceae; Thiotrichales; Proteobacteria; Bacteria

General Information: Isolated from an immunocompetent 56-year old male with bacteremic pneumonia in France. Francisella tularensis is a non-motile, aerobic, rod-shaped Gram-negative bacterium and is the causative agent of tularemia. This organism was first identified by Edward Francis as the causative agent of a plague-like illness that affected squirrels in Tulare county in California in the early part of the 20th century. The organism now bears his name. The disease, which has been noted throughout recorded history, can be transmitted to humans by infected ticks or deerflies, infected meat, or by aerosol, and thus is a potential bioterrorism agent. This organism has a high infectivity rate, and can invade phagocytic and nonphagocytic cells, multiplying rapidly. Once within a macrophage, the organism can escape the phagosome and live in the cytosol. It is an aquatic organism, and can be found living inside protozoans, similar to what is observed with Legionella.

Subject: NC_011979:2641500 Geobacter sp. FRC-32, complete genome

Lineage: Geobacter daltonii; Geobacter; Geobacteraceae; Desulfuromonadales; Proteobacteria; Bacteria

General Information: This organism is able to reduce uranium and may be useful for in situ bioremediation of uranium. An iron(III)-reducing bacterium isolated from the uranium-contaminated subsurface of the U.S. Department of Energy NABIR Field Research Center (FRC), Oak Ridge, Tennessee, USA. Several recent studies have verified using cultivation-independent methods that the Geobacteraceae are predominant in subsurface environments where dissimilatory metal reduction is important to the remediation of uranium and other contaminants.