Query: NC_009720:216589 Xanthobacter autotrophicus Py2, complete genome Lineage: Xanthobacter autotrophicus; Xanthobacter; Xanthobacteraceae; Rhizobiales; Proteobacteria; Bacteria General Information: Alkene-degrading bacterium. Xanthobacter autotrophicus is a nitrogen-fixing methylotroph, commonly isolated from organic rich soil, sediment and water. This organism uses an alkene-specific monooxygenase to convert propene to epoxypropane. This monooxygenase is also able to catalyze the initial step in the cometabolism of chlorinated alkenes such as vinyl chloride and trichloroethene. The Xanthobacter autotrophicus alkene monooxygenase and other genes involved in alkene degradation are located on a 320 kb megaplasmid.
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General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.