Query: NC_009718:1272296 Fervidobacterium nodosum Rt17-B1, complete genome Lineage: Fervidobacterium nodosum; Fervidobacterium; Thermotogaceae; Thermotogales; Thermotogae; Bacteria General Information: Fervidobacterium nodosum is a thermophilic, Gram-negative, motile, non-sporulating, glycolytic, obligately anaerobic rod that exists singly, in pairs or in chains. Fervidobacterium nodosum was isolated from a hot spring in New Zealand. Its optimal growth temperature is 65 to 70 degrees Celsius. The cellular morphology of this organism, a member of the Thermotogales, is characterized by a terminal spherical extension of the cell envelope.
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General Information: This strain is a standard laboratory strain. It is virulent for humans and cattle. Causes bovine brucellosis. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism was first noticed on the island of Malta. It is the primary cause of bovine brucellosis, which results in enormous (billions of dollars) economic losses due primarily to reproductive failure and food losses. In man, it causes undulant fever, a long debilitating disease that is treated by protracted administration of antibiotics.