Pre_GI: SWBIT SVG BLASTP

Query: NC_009697:3711692 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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BLASTP Alignment.txt

Subject: NC_011768:4571869 Desulfatibacillum alkenivorans AK-01, complete genome

Lineage: Desulfatibacillum alkenivorans; Desulfatibacillum; Desulfobacteraceae; Desulfobacterales; Proteobacteria; Bacteria

General Information: Desulfatibacillum alkenivorans AK-01 was isolated from sediment from the Arthur Kill, NJ/NY waterway, USA. This site has a history of contamination from petrochemical industry and strain AK-01 is able to degrade 13 to 18 carbon alkanes. Desulfatibacillum alkenivorans is an alkene-degrading, sulfate-reducing bacterium isolated from estuarine sediment. It activates alkanes via subterminal addition of the alkane to fumarate.