Pre_GI: SWBIT SVG BLASTP

Query: NC_009674:2551759 Bacillus cytotoxicus NVH 391-98 chromosome, complete genome

Lineage: Bacillus cytotoxicus; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: Isolated from a food poisoning outbreak in a nursing home for elderly people in France in March 1998. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. Bacillus cytotoxicus is a member of the Bacillus cereus group, which represents sporulating soil bacteria containing pathogenic strains which may cause food poisoning outbreaks.

Subject: NC_007799:727798 Ehrlichia chaffeensis str. Arkansas, complete genome

Lineage: Ehrlichia chaffeensis; Ehrlichia; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain is the first isolate of Ehrlichia chaffeensis, which was obtained from a patient on an army base in Arkansas, USA in 1990. Causes disease in humans. This organism is an obligate intracellular pathogen that exists within vacuoles in the cytoplasm of monocytes or granulocytes. Transferred during an insect (tick) bite, it can cause disease in humans (human monocytic ehrlichiosis) and can reside in several other animals and is a problem in immunocompromised patients. The bacterium inhibits phagosome-lysozome fusion as well as programmed cell death (apoptosis) of the host cell, similar to what is observed with Anaplasma phagocytophilum.