Pre_GI: SWBIT SVG BLASTP

Query: NC_009668:445134 Ochrobactrum anthropi ATCC 49188 chromosome 2, complete sequence

Lineage: Ochrobactrum anthropi; Ochrobactrum; Brucellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Soil bacterium that can cause opportunistic infections. Ochrobactrum anthropi is an opportunistic human pathogen usually causing infection in association with indwelling medical devices, such as catheters and drainage tubes. This organism and related species have also been isolated from soil, activated sludge, and plants. Ochrobactrum anthropi is a Gram-negative, anaerobic, motile bacterium. A common soil bacteria, it was originally considered as an opportunistic pathogen, causing infections in immunocompromised patients, patients with indwelling catheters or peritoneal dialysis but it is now emerging as a more and more important nosocomial pathogen. The first case of human infection was described in 1980. It has been isolated from blood, the urogenital tract, respiratory tract and eyes, and it can be part of the normal intestinal flora. It is resistant to many antibiotics, especially the beta-lactams.

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BLASTP Alignment.txt

Subject: NC_003103:266013 Rickettsia conorii str. Malish 7, complete genome

Lineage: Rickettsia conorii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from a human in South Africa. Causative agent for Rocky Mountain spotted fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes Rocky Mountain spotted fever which can cause severe damage to the endothelial layer of major organs, including the lungs, heart, kidneys, and skeletal muscle which can result in death.