Query: NC_009655:866281 Actinobacillus succinogenes 130Z chromosome, complete genome
Lineage: Actinobacillus succinogenes; Actinobacillus; Pasteurellaceae; Pasteurellales; Proteobacteria; Bacteria
General Information: Succinate-producing bacterium. Originally isolated from bovine rumen, this species is one of the most promising succinate producers known. It can utilize a variety of sugars and produce a very high volume of succinate, which is used by the pharmaceutical industry. This organism has been improved over time by growth on fermentable carbon and sodium monofluoroacetate and selection of fluoroacetate-resistant mutants which have a higher succinate yield. The succinate yield has also been improved via a metabolic engineering approach, by cloning and overproducing the PEP-carboxykinase gene which catalyzes the addition of carbon dioxide to PEP to form oxalacetate and can work physiologically in both directions
Subject: NC_010634:1175404 Yersinia pseudotuberculosis PB1/+, complete genome
Lineage: Yersinia pseudotuberculosis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria
General Information: Environmental bacterium that causes gastrointestinal disease. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. This organism was first isolated in 1883 by Malassez and Vignal and is termed pseudotuberculosis since it causes lesions in the lung that are similar to those observed during tuberculosis infection. It is ubiquitous in the environment and is a food and waterborne pathogen that affects animals as well as humans by causing gastroenteritis like Yersinia enterocolitica.