Query: NC_009655:2148433 Actinobacillus succinogenes 130Z chromosome, complete genome Lineage: Actinobacillus succinogenes; Actinobacillus; Pasteurellaceae; Pasteurellales; Proteobacteria; Bacteria General Information: Succinate-producing bacterium. Originally isolated from bovine rumen, this species is one of the most promising succinate producers known. It can utilize a variety of sugars and produce a very high volume of succinate, which is used by the pharmaceutical industry. This organism has been improved over time by growth on fermentable carbon and sodium monofluoroacetate and selection of fluoroacetate-resistant mutants which have a higher succinate yield. The succinate yield has also been improved via a metabolic engineering approach, by cloning and overproducing the PEP-carboxykinase gene which catalyzes the addition of carbon dioxide to PEP to form oxalacetate and can work physiologically in both directions
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General Information: Aggregatibacter actinomycetemcomitans D11S-1 was recovered from a subject with aggressive periodontitis. Aggregatibacter actinomycetemcomitans, previously Actinobacillus actinomycetemcomitans typically resides in the oral cavity of humans and animals and can cause a number of diseases. The bacterium, along with 3 other organisms, is the main culprit in periodontis, which results in devastation to the bone supporting the teeth. Adherence to oral surfaces is controlled through the tad (tight adherence) locus, which may express proteins that are involved in type IV secretion.