Query: NC_009648:3192483 Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genome Lineage: Klebsiella pneumoniae; Klebsiella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: This strain was isolated from a patient in 1994. Opportunistic pathogen that causes multiple hospital-acquired infections. This organism is the most medically important organism within the genus Klebsiella. It is an environmental organism found in water, soil, and on the surface of plants. Several strains have been isolated from plant tissues and are nitrogen-fixing endophytes that may be a source of nitrogen for the plant. Other strains can become opportunistic pathogens which infect humans, and typically causes hospital-acquired infections in immunocompromised patients. Major sites of infection include the lungs, where it causes a type of pneumonia, and urinary tract infections. Klebsiella can also enter the bloodstream (bacterimia) and cause sepsis. The pathogen can also infect animals and cause inflammation of the uterus in horses as well as more generalized infections in other mammals. This organism expresses numerous pathogenicity factors, including multiple adhesins, capsular polysaccharide, siderophores, and lipopolysaccharide for the evasion of host defenses. The multiple antibiotic resistance genes carried on the chromosome inhibit efforts to clear the organism from infected patients via antibiotic use.
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General Information: While pathogenic on Arabidopsis thaliana, it is mainly characterized as causing bacterial speck disease on tomato plants, which has a large economic impact. This organism is mainly endophytic and is a poor colonizes of plant surfaces but can multiply within the host. Bacteria belonging to the Pseudomonas group are common inhabitants of soil and water and can also be found on the surfaces of plants and animals. Pseudomonas bacteria are found in nature in a biofilm or in planktonic form. Pseudomonas bacteria are renowned for their metabolic versatility as they can grow under a variety of growth conditions and do not need any organic growth factors. This species includes many plant pathogens of important crops, which makes it a model organism in plant pathology. Its natural environment is on the surface of plant leaves and it can withstand various stressful conditions, like rain, wind, UV radiation and drought. It can colonize plants in a non-pathogenic state and can rapidly take advantage of changing environmental conditions to induce disease in susceptible plants by shifting gene expression patterns.