Query: NC_009633:4308016 Alkaliphilus metalliredigens QYMF chromosome, complete genome Lineage: Alkaliphilus metalliredigens; Alkaliphilus; Clostridiaceae; Clostridiales; Firmicutes; Bacteria General Information: This bacterium is an alkiphilic, moderately halophilic metal-reducing bacterium isolated from borax leachate ponds. It can reduce iron and other metals under alkaline conditions.
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General Information: This strain was isolated from a case of relapsing fever in western Washington, USA. Borrelia hermsii is the causative agent of tick-borne relapsing fever in the western United States and Canada. Borrelia then multiplies rapidly, causing a generalized infection throughout the tick. While feeding, the tick passes the organism into a mammalian host through its infectious saliva. Relapsing fever is characterized by a period of chills, fever, headache, and malaise, an asymptomatic period, followed by another episode of symptoms. This cycle of relapsing is due to changes in the surface proteins of Borrelia, which allow it to avoid detection and removal by the host immune system. This antigenic variation is the result of homologous recombination of silent proteins into an expressed locus, causing partial or complete replacement of one serotype with another. These plasmids carry genes involved in antigenic variation and pathogenicity.