Query: NC_009616:99647 Thermosipho melanesiensis BI429 chromosome, complete genome Lineage: Thermosipho melanesiensis; Thermosipho; Thermotogaceae; Thermotogales; Thermotogae; Bacteria General Information: BI429 (CIP 104789) is the type strain for this species and was isolated from the gills of Bathymodiolus brevior, a deep-sea mussel. The sample was taken from the Lau Basin at the bottom of a black smoker between 1832 and 1887 metres. Thermosipho melanesiensis is a deep-sea thermophilic marine organism closely related to a hot springs isolate, T. africanus.
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General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.