Query: NC_009616:1433430 Thermosipho melanesiensis BI429 chromosome, complete genome Lineage: Thermosipho melanesiensis; Thermosipho; Thermotogaceae; Thermotogales; Thermotogae; Bacteria General Information: BI429 (CIP 104789) is the type strain for this species and was isolated from the gills of Bathymodiolus brevior, a deep-sea mussel. The sample was taken from the Lau Basin at the bottom of a black smoker between 1832 and 1887 metres. Thermosipho melanesiensis is a deep-sea thermophilic marine organism closely related to a hot springs isolate, T. africanus.
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General Information: Causes bovine brucellosis. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism was first noticed on the island of Malta by Dr. David Bruce during an epidemic among British soldiers. It is the primary cause of bovine brucellosis, which results in enormous (billions of dollars) economic losses due primarily to reproductive failure and food losses. In man, it causes undulant fever, a long debilitating disease that is treated by protracted administration of antibiotics.