Query: NC_009505:264963 Brucella ovis ATCC 25840 chromosome I, complete sequence Lineage: Brucella ovis; Brucella; Brucellaceae; Rhizobiales; Proteobacteria; Bacteria General Information: This strain was isolated from sheep tissue in Australia. Causes brucellosis in sheep. This organism specifically affects sheep, causing ovine brucellosis which results in significant economic losses. Infection by the organism can cause infertility in rams as the bacterium preferentially colonizes the genital tract, and causes inflammation of the epididymis which leads to necrotic lesions and a decrease in sperm numbers and motility. This bacterium, like other Brucella, is an intracellular pathogen that infects phagocytic cells such as macrophages. Bacterial cells produces a lipopolysaccharide that lacks O-antigen side chains, which results in a rough colony phenotype, and aids in differentiation as compared to other Brucella.
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General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.