Query: NC_009488:327285 Orientia tsutsugamushi str. Boryong, complete genome Lineage: Orientia tsutsugamushi; Orientia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria General Information: This strain was isolated from a human in 1995 in Boryong, Korea. Causal agent of scrub typhus. This organism is the causative agent of scrub typhus, and like other members of the Rickettsiales is an obligate intracellular organism. Scrub typhus, which occurs in rural and agricultural areas, is one of the most common infectious diseases in southeast Asia where an estimated 1 million cases occur each year. Many cases are mild, but if left untreated, a variety of serious illnesses can arise and fatality rates can range from 1-35%. Transmission occurs via an insect vector through the bite of the larval trombiculid mite (chiggers). The bacterium is transmitted transovarially in mites (from females to their offspring).
- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description
General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.