Query: NC_009484:98250 Acidiphilium cryptum JF-5 chromosome, complete genome Lineage: Acidiphilium cryptum; Acidiphilium; Acetobacteraceae; Rhodospirillales; Proteobacteria; Bacteria General Information: Acidiphilium cryptum strain JF-5 was isolated under iron-reducing conditions from coal mine lake sediment and is able to grow by coupling the reduction of iron to the oxidation of glucose. Iron-reducing acidophile. Acidiphilium cryptum was first isolated from a supposedly pure culture of Thiobacillus ferrooxidans. This organism, a heterotrophic acidophile, has been isolated from acid mine drainage, hydrothermal vent water, and other acidic mineral environments.
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General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.