Pre_GI: SWBIT SVG BLASTP

Query: NC_009381:3094939 Yersinia pestis Pestoides F chromosome, complete genome

Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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BLASTP Alignment.txt

Subject: NC_015633:413587 Vibrio anguillarum 775 chromosome chromosome I, complete sequence

Lineage: Vibrio anguillarum; Vibrio; Vibrionaceae; Vibrionales; Proteobacteria; Bacteria

General Information: Listonella anguillarum, formerly Vibrio anguillarum is an opportunistic pathogen in economically important marine fish such as eel, flounder and salmon. This disease causes lesions on the skin and around the mouth and gills of the fish often progressing to a systemic infection causing death. If left untreated this disease can cause significant losses in commercial hatcheries.