Query: NC_009380:3148363 Salinispora tropica CNB-440 chromosome, complete genome Lineage: Salinispora tropica; Salinispora; Micromonosporaceae; Actinomycetales; Actinobacteria; Bacteria General Information: This strain was isolated from coarse beach sand off the Bahamas. An obligate marine actinomycete. Salinispora strains are commonly isolated from tropical marine sediment. Members of this genus produce branched hyphae and require media which contain seawater or sodium. A survey of the cultured species identified over 90 isolates which produce compounds that inhibited cancer cells. These organisms may be a new source of bioactive chemicals for use in disease and cancer treatments. This species produces the chemicals salinosporamide A and B which may be useful for cancer treatment.
- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description
General Information: Sorangium cellulosum 'So ce 56' produces a large number of bioactive compounds, such as, the antifungal soraphen and the anticancer agent epothilone. This organism, like other myxobacteria, undergoes a complex development and differentiation pathway. When cell density increases, the organism switches to "social motility" where aggregates of cells can gather together into masses termed fruiting bodies that may consist of up to 100 000 cells. The motility system is not dependent on flagella like most bacteria, but instead relies on twitching pili: short extracellular appendages that may function analogously to oars in a rowboat. The myxobacteria have proved to be a rich source of novel natural products. Sorangium cellulosum produces a number of antibacterial, antifungal and cytotoxic substances which are being studies for therapeutic applications.