Query: NC_009342:2528426 Corynebacterium glutamicum R chromosome, complete genome Lineage: Corynebacterium glutamicum; Corynebacterium; Corynebacteriaceae; Actinomycetales; Actinobacteria; Bacteria General Information: This strain was isolated from meadow soil in Japan. Soil bacterium with industrial uses. They may be found as members of the normal microflora of humans, where these bacteria find a suitable niche in virtually every anatomic site. This organism is a well-studied soil bacterium of considerable importance in biotechnology, in particular for the fermentative production of L-amino acids for food and fodder industry. The name was originaly given for this species for its ability to produce significant quantities (>100 g per liter) of glutamic acid (glutamate), an important food enhancer that has a meaty taste and flavor. C. glutamicum is currently used commercially to produce glutamate and other amino acids (L-lysine) and compounds. The first strain of the species was isolated in 1957 by S. Kinoshita and colleagues while searching for an efficient glutamate-producer.
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General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.