Query: NC_009328:3504454 Geobacillus thermodenitrificans NG80-2 chromosome, complete genome Lineage: Geobacillus thermodenitrificans; Geobacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria General Information: Geobacillus thermodenitrificans NG80-2 was isolated from oil reservoir formation water taken at a depth of 2000 m and a temperature of 73 degrees C. This strain can use crude oil as a sole carbon source and can degrade 16 to 36 carbon alkanes. Geobacillus thermodenitrificans NG80-2 produces an emulsifier which may be useful for high temperature biodegradation or other industrial purposes. Members of this genus were originally classified as Bacillus. Recent rDNA analysis and DNA-DNA hybridization studies using spore-forming thermophilic subsurface isolates provided enough evidence to define the phylogenetically distinct, physiologically and morphologically consistent taxon Geobacillus. Geobacillus species are chemo-organotrophic, obligately thermophilic, motile, spore-forming, aerobic or facultatively anaerobic.
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General Information: This strain probably caused lethal anthrax in chimpanzee Leo in the rainforest of the Tai National Park, Cote d'Ivoire. It belongs to a collection of genetically closely related bacteria, isolated in 2001 and 2002 from deceased wild chimpanzees living in this rain forest area. An autopsy showed symptoms typical of anthrax, but the bacterium isolated was motile, unlike B.anthracis. This organism is a soil-dwelling opportunistic pathogen that causes food poisoning in infected individuals. The rapid onset is characterized by nausea and vomiting while the late onset is characterized by diarrhea and abdominal pain. The emetic disease is caused by a small stable dodecadepsipeptide cerulide whereas the diarrheal disease is caused by a heat labile enterotoxin. Some strains produce a potent cytotoxin that forms a pore in the membrane of eukaryotic cells and causes necrotic enteritis (death of intestinal epithelial cells) while the unique tripartite membrane lytic toxin hemolysin BL contributes to the diarrheal disease and destructive infections of the eye.