Pre_GI: SWBIT SVG BLASTP

Query: NC_009257:109528 Francisella tularensis subsp. tularensis WY96-3418 chromosome,

Lineage: Francisella tularensis; Francisella; Francisellaceae; Thiotrichales; Proteobacteria; Bacteria

General Information: This strain was isolated from a human finger wound. Causative agent of tularemia. This organism was first identified by Edward Francis as the causative agent of a plague-like illness that affected squirrels in Tulare county in California in the early part of the 20th century. The organism now bears his name. The disease, which has been noted throughout recorded history, can be transmitted to humans by infected ticks or deerflies, infected meat, or by aerosol, and thus is a potential bioterrorism agent. This organism has a high infectivity rate, and can invade phagocytic and nonphagocytic cells, multiplying rapidly. Once within a macrophage, the organism can escape the phagosome and live in the cytosol. It is an aquatic organism, and can be found living inside protozoans, similar to what is observed with Legionella.

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Subject: NC_010424:214640 Candidatus Desulforudis audaxviator MP104C, complete genome

Lineage: Desulforudis audaxviator; Desulforudis; Peptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Its genome indicates a motile, sporulating, sulfate-reducing, chemoautotrophic thermophile that can fix its own nitrogen and carbon by using machinery shared with archaea. Candidatus Desulforudis audaxviator is a gram positive sulfate reducing bacteria identified in fracture water from a borehole at a depth of 2.8 km in a South African gold mine. Water from these boreholes is very old (low-biodiversity fracture water), suggesting that these bacteria have been isolated from the Earth's surface for as much as several million years.