Query: NC_009142:2480608 Saccharopolyspora erythraea NRRL 2338, complete genome Lineage: Saccharopolyspora erythraea; Saccharopolyspora; Pseudonocardiaceae; Actinomycetales; Actinobacteria; Bacteria General Information: Source of the antibiotic erythromycin. Saccharopolyspora erythraea is the soil bacterium that produces the industrially important antibiotic erythromycin A. Erythromycin is a clinically important and potent macrolide antibiotic. It is used to treat infections caused by several prokaryotic pathogens such as Streptococcus, Staphylococcus, Mycoplasma, Ureaplasma, Chlamydia and Legionella. Production of this antibiotic is lower than others in the same class, such as penicillin or cephalosporin, which has led to the development of a genetic system to attempt to enhance the production of erythromycin.
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General Information: Country: USA; Temp: Mesophile; Temp: 28 - 36C; Habitat: Marine, Skin microflora. Strain DSM 20547, the type strain, is a free-living, nonmotile, Gram-positive bacterium, originally isolated from a marine environment in about 1944. It grows as spherical/coccoid and occurs predominantly in tetrads which can be arranged in cubical packets. It is non-encapsulated and does not form endospores, is strictly aerobic and chemoorganotrophic, requires methionine and other amino acids for growth, and grows well in NaCl at concentrations up to 10% (w/v). This organism is a normal commensal of human skin, however has been implicated in pitted keratolysis, pneumonia, and other opportunistic infections.