Pre_GI: SWBIT SVG BLASTP

Query: NC_008800:2013450 Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,

Lineage: Yersinia enterocolitica; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This isolate (strain 8081; NCTC 13174) is a mouse-lethal serotype of Yersinia enterocolitica that contains a high pathogenicity island (HPI) that encodes an iron uptake system (yersiniabactin) and a type II secretion system. Causes gastroenteritis. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. This species is a food and waterborn pathogen that causes gastroenteritis (inflammation of the mucous membranes of the stomach and intestine) and is able to proliferate at temperatures as low as 4 degrees C.

Subject: NC_003454:249304 Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete

Lineage: Fusobacterium nucleatum; Fusobacterium; Fusobacteriaceae; Fusobacteriales; Fusobacteria; Bacteria

General Information: Normal oral and gastrointestinal bacterium. This genus contains mostly obligately anaerobic bacilli. Many of the isolates are spindle-shaped, or fusiform. This organism belongs to the normal microflora of the human oral and gastrointestinal tracts. It is a very long and slender spindle-shaped bacillus with sharply pointed ends that is characterized by the ability to invade soft tissues. It acts as a bridge between early and late colonizers of the tooth surface, and exerts synergism with other bacteria in mixed infections. It is most frequently associated with periodontal diseases, as well as with some invasive human infections of the head and neck, chest, lung, liver and abdomen, and some anginas. One of the major amino acid and sugar fermentation pathways in Fusobacterium nucleatum produces butyric and acetic acids.