Pre_GI: SWBIT SVG BLASTP

Query: NC_008787:437786 Campylobacter jejuni subsp. jejuni 81-176, complete genome

Lineage: Campylobacter jejuni; Campylobacter; Campylobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain (81-176; Penner serotype 23/36) was isolated during an outbreak of campylobacteriosis in Minnesota, USA, due to the consumption of contaminated milk. This organism is the leading cause of bacterial food poisoning (campylobacteriosis) in the world, and is more prevalent than Salmonella enteritis (salmonellosis). Found throughout nature, it can colonize the intestines of both mammals and birds, and transmission to humans occurs via contaminated food products. This organism can invade the epithelial layer by first attaching to epithelial cells, then penetrating through them. Systemic infections can also occur causing more severe illnesses.

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BLASTP Alignment.txt

Subject: NC_004917:340997 Helicobacter hepaticus ATCC 51449, complete genome

Lineage: Helicobacter hepaticus; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This organism was found to be linked to an increasing incidence of liver tumors in mouse colonies at the National Cancer Institute in 1992. Normally it resides in the lower intestines, but it can cause chronic hepatitis. This organism has a similar urease gene cluster and cytolethal distending toxin as compared to Helicobacter pylori, but lacks other virulence factors such as the vacuolating cytotoxin and the cag pathogenicity island. However, it does contain a pathogenicity island that encodes proteins similar to those found in a type IV secretion system. Causes liver disease. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). This species was associated with an increase in liver tumors. It can cause active chronic hepatitis and typhlitis (inflammation of a region at the beginning of the large intestine), hepatocellular tumors, and gastric bowel disease in various mice strains.