Query: NC_008699:3516608 Nocardioides sp. JS614, complete genome Lineage: Nocardioides; Nocardioides; Nocardioidaceae; Actinomycetales; Actinobacteria; Bacteria General Information: This bacterium grows quickly and efficiently on media containing vinyl chloride and ethene. If starved of vinyl chloride for one day, it will not recover for more than 40 days. This strain was placed in the Nocardioides genus on the basis of 16S rRNA analysis.
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General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.