Pre_GI: SWBIT SVG BLASTP

Query: NC_008593:2020473 Clostridium novyi NT, complete genome

Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

Subject: NC_005303:553500 Onion yellows phytoplasma OY-M, complete genome

Lineage: Onion yellows phytoplasma; Phytoplasma; Acholeplasmataceae; Acholeplasmatales; Tenericutes; Bacteria

General Information: This strain (OY-M) is derived from a wild-type disease-causing strain (OY-W; onions yellow disease) which was isolated in Saga Prefecture, Japan, in 1982, and shows mild symptoms and does not cause stunting nor phloem hyperplasia (excessive increase in number of cells). Plant pathogenic bacterium. Phytoplasmas inhabit phloem (food-conducting vascular tissue) sieve elements of plants where they cause a variety of diseases. There is great interest in sequencing these organisms since they are currently unculturable and examination of the genome may lead to methods to deal with the diseases they cause including the development of antimicrobial agents. There is great interest in sequencing these organisms since they are currently unculturable and examination of the genome may lead to methods to deal with the diseases they cause including the development of antimicrobial agents.