Pre_GI: SWBIT SVG BLASTP

Query: NC_008593:1461771 Clostridium novyi NT, complete genome

Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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BLASTP Alignment.txt

Subject: NC_010830:923266 Candidatus Amoebophilus asiaticus 5a2, complete genome

Lineage: Amoebophilus asiaticus; Amoebophilus; Amoebophilaceae; Cytophagales; Bacteroidetes; Bacteria

General Information: Candidatus Amoebophilus asiaticus 5a2 is an obligate endosymbiont found in Acanthamoeba sp. TUMSJ-321. This organism is a member of the highly diverse bacterial phylum Bacteroidetes which includes the endosymbiont lineages represented by the sister taxa Candidatus A. asiaticus and Candidatus Cardinium hertigii, a symbiont of arthropods.