Query: NC_008571:2926067 Gramella forsetii KT0803, complete genome
Lineage: Gramella forsetii; Gramella; Flavobacteriaceae; Flavobacteriales; Bacteroidetes; Bacteria
General Information: Aquatic bacterium. This species was isolated from concentrated seawater collected from the German Bight in the North Sea, during a phytoplankton bloom. Surface waters were sampled weekly, and bacteria were grown on agar plates enriched with synthetic seawater medium.
Subject: NC_011896:2240990 Mycobacterium leprae Br4923, complete genome
Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.