Query: NC_008510:995612 Leptospira borgpetersenii serovar Hardjo-bovis JB197 chromosome 1, Lineage: Leptospira borgpetersenii; Leptospira; Leptospiraceae; Spirochaetales; Spirochaetes; Bacteria General Information: This strain is lethal in hamsters. This strain is lethal in hamsters. This organism is a bacterial pathogen of cattle. This organism colonizes in the kidney and reproductive tracts of infected animals. There is also a risk of zoonotic infections in humans, especially those who work with cattle.
- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description
General Information: Causative agent for Rocky Mountain Spotted Fever. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.