Query: NC_008391:404388 Burkholderia cepacia AMMD chromosome 2, complete sequence Lineage: Burkholderia ambifaria; Burkholderia; Burkholderiaceae; Burkholderiales; Proteobacteria; Bacteria General Information: Isolated from the rhizosphere of healthy pea plants in Wisconsin, USA, in 1985. Pathogenic in cystic fibrosis patients. These bacteria present great versatility to adapt to diverse environments, and are capable of degrading pollutants in water and soil, and fixing atmospheric nitrogen. This species include strains isolated from cystic fibrosis patients as well as strains with potential use in biocontrol.
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General Information: Sorangium cellulosum 'So ce 56' produces a large number of bioactive compounds, such as, the antifungal soraphen and the anticancer agent epothilone. This organism, like other myxobacteria, undergoes a complex development and differentiation pathway. When cell density increases, the organism switches to "social motility" where aggregates of cells can gather together into masses termed fruiting bodies that may consist of up to 100 000 cells. The motility system is not dependent on flagella like most bacteria, but instead relies on twitching pili: short extracellular appendages that may function analogously to oars in a rowboat. The myxobacteria have proved to be a rich source of novel natural products. Sorangium cellulosum produces a number of antibacterial, antifungal and cytotoxic substances which are being studies for therapeutic applications.