Query: NC_008358:2808299 Hyphomonas neptunium ATCC 15444, complete genome Lineage: Hyphomonas neptunium; Hyphomonas; Hyphomonadaceae; Rhodobacterales; Proteobacteria; Bacteria General Information: Marine member of dimorphic prosthecate bacteria. This organism is also known as Hyphomicrobium neptunium. It has a biphasic life style, which consists of a motile phase of flagellated swarmer cells, and a cessile phase in which a long prosthecate is produced at one end of the bacteria through which budding cells emerge. Newly budded cells in turn produce flagella and go through a motile phase and the cycle continues. These organisms can colonize the surfaces of marine environments which enables additional species to colonize at later stages. This organism may be of use in treatment of water as they attach to a solid surface and are capable of degradation of a number of pollutants including aromatic hydrocarbons, dimethyl sulfoxide and methyl chloride.
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General Information: This strain was isolated from human gingiva. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.