Query: NC_008343:2589680 Granulibacter bethesdensis CGDNIH1, complete genome Lineage: Granulibacter bethesdensis; Granulibacter; Acetobacteraceae; Rhodospirillales; Proteobacteria; Bacteria General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.
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General Information: Nitrite-oxidizing bacterium. Members of this genus are found in marine, freshwater, and terrestrial habitats, often in association with ammonia-oxidizing bacteria. These organisms oxidize nitrate, generated by the oxidation of ammonia, to nitrate and play an important role in the global nitrogen cycle. The enzyme involved in nitrite oxidation, nitrite oxidoreductase, can also reduce nitrate to nitrite in the absence of oxygen, allowing Nitrobacter sp. to grow anaerobically. Nitrobacter winogradskyi is commonly isolated from soil, fresh and sea water, sewage, and compost. This organism can grow anaerobically using nitrate as the electron acceptor, forming nitrite, nitric oxide, and nitrous oxide.