Query: NC_008343:2020785 Granulibacter bethesdensis CGDNIH1, complete genome
Lineage: Granulibacter bethesdensis; Granulibacter; Acetobacteraceae; Rhodospirillales; Proteobacteria; Bacteria
General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.
Subject: NC_006624:2016000 Thermococcus kodakarensis KOD1, complete genome
Lineage: Thermococcus kodakarensis; Thermococcus; Thermococcaceae; Thermococcales; Euryarchaeota; Archaea
General Information: This organism was originally identified as Pyrococcus sp. strain KOD1. It was isolated from a solfatara on Kodakara Island, Japan. Hyperthermophilic archeon. This genus is a member of the order Thermococcales in the Euryarchaeota. Thermococcus sp. are the most commonly isolated hyperthermophilic organisms and are often isolated from marine hydrothermal vents and terrestrial hot sulfur springs. Elemental sulfur is either required for, or stimulates, growth. These obligate heterotrophs can ferment a variety of organic compounds, including peptides, amino acids, and sugars in the absence of sulfur. Thermococcus kodakaraensis is a hyperthermophilic archeon. Proteins from this organism have been extensively studied to find thermostable enzymes for industrial and biotechnological applications.