Query: NC_008343:1699132 Granulibacter bethesdensis CGDNIH1, complete genome Lineage: Granulibacter bethesdensis; Granulibacter; Acetobacteraceae; Rhodospirillales; Proteobacteria; Bacteria General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.
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General Information: This species was isolated from the kidney of the earthworm Eisenia foetida. Evidence based on curing experiments, Acidovorax-specific probes, and 16S phylogeny, indicate that earthworm egg capsules contain high numbers of the bacterial endosymbiont. Juvenile earthworms are colonized during embryonic development within the egg capsule, and failing this are not likely to acquire the symbiont by association with colonized adults or their bedding.