Query: NC_008277:387811 Borrelia afzelii PKo, complete genome
Lineage: Borrelia afzelii; Borrelia; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria
General Information: Causative agent of Lyme borreliosis. This species was isolated from a skin lesion from a Lyme disease patient in Europe in 1993. It is a specific aetological agent of acrodermatitis chronica atrophicans (ACA). This organism can be differentiated from other Borrelia species by monoclonal antibody hybridization.
Subject: NC_007799:968499 Ehrlichia chaffeensis str. Arkansas, complete genome
Lineage: Ehrlichia chaffeensis; Ehrlichia; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria
General Information: This strain is the first isolate of Ehrlichia chaffeensis, which was obtained from a patient on an army base in Arkansas, USA in 1990. Causes disease in humans. This organism is an obligate intracellular pathogen that exists within vacuoles in the cytoplasm of monocytes or granulocytes. Transferred during an insect (tick) bite, it can cause disease in humans (human monocytic ehrlichiosis) and can reside in several other animals and is a problem in immunocompromised patients. The bacterium inhibits phagosome-lysozome fusion as well as programmed cell death (apoptosis) of the host cell, similar to what is observed with Anaplasma phagocytophilum.