Pre_GI: SWBIT SVG BLASTP

Query: NC_008258:1076922 Shigella flexneri 5 str. 8401, complete genome

Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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BLASTP Alignment.txt

Subject: NC_008570:1986466 Aeromonas hydrophila subsp. hydrophila ATCC 7966, complete genome

Lineage: Aeromonas hydrophila; Aeromonas; Aeromonadaceae; Aeromonadales; Proteobacteria; Bacteria

General Information: Isolated from canned milk from the USA. Aquatic organism that can cause foodborne illnesses in humans. This organism is an enviromental bacterium that is often found in aquatic habitats, but can also be found contaminating food products. It causes a variety of diseases in both cold-blooded and warm-blooded organisms. The bacterium is becoming a problematic pathogen in humans, where it causes gastroenteritis and septicemia, mainly due to the development of antibiotic resistance by this organism. One of the major virulence factors is aerolysin, a toxin that is produced and secreted by the cell via a type II secretion apparatus. Other virulence functions include a surface layer which inhibits complement-mediated killing, type IV pili for attachment, and a set of extracellular proteases which can cause tissue damage.