Query: NC_008209:695269 Roseobacter denitrificans OCh 114, complete genome Lineage: Roseobacter denitrificans; Roseobacter; Rhodobacteraceae; Rhodobacterales; Proteobacteria; Bacteria General Information: The aerobic phototrophic bacteria are ubiquitous as plant symbionts, free-living in lakes and ocean surface waters, soils and even near deep sea hydrothermal vents. Marine bacterium capable of aerobic anoxygenic photosynthesis. This bacterium was first isolated from a marine sediment collected on the coast of Australia. This organism's PufC photosynthetic protein has been studied as a classical tetraheme cytochrome, as it has all four possible heme-binding motifs.
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General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.